Rev. OFIL 2017, 27;1:85-87
Fecha de recepción: 20/06/2016 – Fecha de aceptación: 20/09/2016
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Gómez-Álvarez S1, Sancho-Calabuig MA2, Hermenegildo-Caudevilla M3, Climente-Martí M4
1 Farmacéutico Especialista. Sevicio de Farmacia
2 Facultativo Especialista. Servicio de Nefrología
3 Facultativo Especialista. Servicio de Farmacia
4 Jefe de Servicio de Farmacia
Hospital Universitario Doctor Peset. Valencia (España)
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Correspondencia:
Sandra Gómez Álvarez
Hospital Universitario Doctor Peset
(Servicio de Farmacia)
Avda. Gaspar Aguilar, 90
46017 Valencia
Correo electrónico: gomal.sandra@gmail.com
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SUMMARY
Prognosis of HIV infection has improved with the introduction of highly active antiretroviral therapy, given the solid organ transplant a therapeutic alternative in these patients with advanced kidney disease. We present a case of drug-drug interaction between tacrolimus and the combination of two protease inhibitors, darunavir and ritonavir, in a kidney transplant recipient infected with a multidrug-resistant HIV strain. Was complicated by the development of nephropathy by BK virus in the graft and pharmacokinetic monitoring allowed for precise adjustment of immunosuppressive treatment, avoiding change antiretroviral therapy and development of chronic nephrotoxicity in the graft.
Key Words: Kidney transplantation, tacrolimus, drug interactions, anti-retroviral agents, BK virus.
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